Genetic heterogeneity of the Spy1336/R28-Spy1337 virulence axis in Streptococcus pyogenes and effect on gene transcript levels and pathogenesis.

Streptococcus pyogenes is a strict human pathogen responsible for more than 700 million infections annually worldwide.Strains of serotype M28 S.pyogenes are typically among the five more abundant types causing invasive infections and pharyngitis in adults and children.Type M28 strains also have an unusual propensity to cause puerperal sepsis and ne

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Targeting SphK1/2 by SKI-178 inhibits prostate cancer cell growth

Abstract Sphingosine kinases (SphK), including SphK1 and SphK2, are important enzymes promoting progression of prostate cancer.SKI-178 is a novel and highly potent SphK1/2 dual inhibitor.We here tested the potential anti-prostate cancer cell activity of SKI-178.Bioinformatics analyses and results from local tissues demonstrated that that both SphK1

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ABOUT INDIRECT TRANSLATION, RECEPTION AND CELEBRITY

This essay is an attempt to find a theoretical point of view for the study of indirect translations of literary works.I try to understand the indirect translations in the same level as the direct translations, without consider the first less significant than the COCONUT OIL ORG VIR second, because are not made from the original texts.So I propose t

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